U.S. Route 221

U.S. Route 221
US 221 highlighted in red
Route information
Auxiliary route of US 21
Length	734 mi (1,181 km)
Existed	1930–present
Major junctions
South end	US 19 / US 27 Alt. / US 98 / SR 55 in Perry, FL
Major intersections	I-10 near Greenville, FL I-75 in Valdosta, GA I-16 near Soperton, GA I-20 near Harlem, GA I-385 near Laurens, SC I-26 in Roebuck, SC I-85 in Spartanburg, SC I-40 in Marion, NC I-77 near Hillsville, VA I-581 in Roanoke, VA
North end	US 29 Bus. / US 460 Bus. / US 501 Bus. at Lynchburg, VA

Location
Country	United States
States	Florida, Georgia, South Carolina, North Carolina, Virginia

Highway system
United States Numbered Highway System List Special Divided

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg, Virginia, at US 29 Business (Lynchburg Expressway). It travels through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia. It travels through the cities of Valdosta, Georgia; Spartanburg, South Carolina; Marion, North Carolina; Roanoke, Virginia; and Lynchburg, Virginia.