U.S. Route 275
| US 275 highlighted in red | ||||||||||
| Route information | ||||||||||
| Auxiliary route of US 75 | ||||||||||
| Length | 265.82 mi (427.80 km) 
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| Major junctions | ||||||||||
| South end | US 136 at Rock Port, MO | |||||||||
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| West end | US 20 / US 281 in O'Neill, NE | |||||||||
| Location | ||||||||||
| Country | United States | |||||||||
| States | Missouri, Iowa, Nebraska | |||||||||
| Highway system | ||||||||||
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U.S. Route 275 (US 275) is a north–south United States Numbered Highway that is a branch of US 75. It originally terminated at US 75 in Council Bluffs, Iowa. The highway's northern terminus is in O'Neill, Nebraska, at an intersection with US 20 and US 281. Its southern terminus is near Rock Port, Missouri, at an intersection with US 136.