U.S. Route 385
| US 385 highlighted in red | |
| Route information | |
| Auxiliary route of US 85 | |
| Length | 1,206 mi (1,941 km) | 
| Existed | 1958–present | 
| Major junctions | |
| South end | Big Bend National Park, TX | 
| 
 | |
| North end | US 85 at Deadwood, SD | 
| Location | |
| Country | United States | 
| States | Texas, Oklahoma, Colorado, Nebraska, South Dakota | 
| Highway system | |
U.S. Route 385 (US 385) is a spur of U.S. Route 85 that runs for 1,206 miles (1,941 km) from Deadwood, South Dakota to Big Bend National Park in Texas.