U.S. Route 4
| US 4 highlighted in red | |||||||
| Route information | |||||||
| Length | 252.62 mi (406.55 km) | ||||||
| Existed | 1926–present | ||||||
| Major junctions | |||||||
| West end | US 9 / US 20 in East Greenbush, NY | ||||||
| 
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| East end | I-95 / Blue Star Turnpike / Spaulding Turnpike / US 1 Byp. / NH 16 in Portsmouth, NH | ||||||
| Location | |||||||
| Country | United States | ||||||
| States | New York, Vermont, New Hampshire | ||||||
| Highway system | |||||||
| 
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U.S. Route 4 (US 4) is a 253-mile-long (407 km) United States Numbered Highway that runs from East Greenbush, New York, in the west to Portsmouth, New Hampshire, in the east, traversing Vermont.
In New York, US 4 is signed north–south to reflect its alignment in the state. In Vermont and New Hampshire, the route is signed east–west, the conventional direction for even-numbered U.S. Routes.