U.S. Route 421 in Kentucky

U.S. Route 421
U.S. Route 421
	US 421 highlighted in red
Route information
	Maintained by KYTC
Length	250.536 mi (403.199 km)
Major junctions
South end	US 421 at the Virginia state line near Pennington Gap, VA
	US 25 from Terrill to Lexington; I-75 in Lexington; US 60 / US 68 / US 27 in downtown Lexington; US 62 in Midway; US 60 / KY 676 in Frankfort; KY 55 from New Castle to Campbellsburg; I-71 near Campbellsburg; US 42 in Bedford;
North end	US 421 at the Indiana state line near Madison
Location
Country	United States
State	Kentucky
Counties	Harlan, Leslie, Clay, Jackson, Rockcastle, Madison, Fayette, Scott, Woodford, Franklin, Shelby, Henry, Trimble
Highway system
	United States Numbered Highway System; List; Special; Divided; Kentucky State Highway System; Interstate; US; State; Parkways;

U.S. Route 421 (US 421) in the U.S. state of Kentucky is a 250.536-mile-long (403.199 km) north–south United States highway that traverses twelve counties in the central and eastern parts of the state. It travels in a southeast-to-northwest path from the Virginia state line near Pennington Gap to the Indiana state line, on the Ohio River at Milton, Kentucky and Madison, Indiana.