U.S. Route 75
| US 75 highlighted in red | ||||
| Route information | ||||
| Length | 1,239 mi (1,994 km) | |||
| Existed | 1926–present | |||
| Major junctions | ||||
| South end | I-345 / Spur 366 at Dallas, TX | |||
| 
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| North end | Canadian border at Noyes, MN; Port of Entry closed | |||
| Location | ||||
| Country | United States | |||
| States | Texas, Oklahoma, Kansas, Nebraska, Iowa, Minnesota | |||
| Highway system | ||||
| 
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U.S. Route 75 is a north–south U.S. Highway that runs 1,239 miles (1,994 km) in the central United States. The highway's northern terminus is located at the Canadian border near Noyes, Minnesota, at a now-closed border crossing. From this point, the highway once continued farther north as Manitoba Highway 75. Its southern terminus is located at Interstate 345 (I-345) and Texas State Highway Spur 366 (Spur 366) in Dallas, Texas, where US 75 is known as North Central Expressway.
US 75 was previously a cross-country route, from Canada to the Gulf of Mexico at Galveston, Texas, but the entire segment south of Dallas has been decommissioned in favor of I-45; a cutoff section of town-to-town surface road having become Texas State Highway 75.