U4atac minor spliceosomal RNA
| U4atac minor spliceosomal RNA | |
|---|---|
Predicted secondary structure and sequence conservation of U4atac | |
| Identifiers | |
| Symbol | U4atac |
| Rfam | RF00618 |
| Other data | |
| RNA type | Gene; snRNA; splicing |
| Domain(s) | Eukaryota |
| GO | GO:0000355 GO:0000369 GO:0030624 GO:0030627 GO:0005690 |
| SO | SO:0000274 |
| PDB structures | PDBe |
U4atac minor spliceosomal RNA is a ncRNA which is an essential component of the minor U12-type spliceosome complex. The U12-type spliceosome is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type).
U4atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U6atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing. U4atac also contains a 3' Sm protein binding site which has been shown to be essential for splicing activity. U4atac is the functional analog of U4 spliceosomal RNA in the major U2-type spliceosomal complex.
The Drosophila U4atac snRNA has an additional predicted 3' stem loop terminal to the Sm binding site.