UBE2A

UBE2A
Identifiers
Aliases	UBE2A, HHR6A, MRXS30, MRXSN, RAD6A, UBC2, ubiquitin conjugating enzyme E2 A
External IDs	OMIM: 312180; MGI: 102959; HomoloGene: 68308; GeneCards: UBE2A; OMA:UBE2A - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	119,591,083 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	36,147,875 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; mucosa of transverse colon; ; placenta; ; rectum; ; epithelium of nasopharynx; ; gastrocnemius muscle; ; right ventricle; ; optic nerve; ; left ventricle; ; monocyte;
	Top expressed in
	endocardial cushion; ; atrium; ; atrioventricular valve; ; medial ganglionic eminence; ; parotid gland; ; dermis; ; right kidney; ; triceps brachii muscle; ; epithelium of stomach; ; blastocyst;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; protein binding; ATP binding; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity;
Cellular component	cytoplasm; cytosol; HULC complex; nucleoplasm; chromatin; XY body;
Biological process	histone H2A ubiquitination; postreplication repair; ubiquitin-dependent protein catabolic process; protein polyubiquitination; cellular response to DNA damage stimulus; protein K11-linked ubiquitination; protein K48-linked ubiquitination; positive regulation of cell population proliferation; response to UV; DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein ubiquitination; in utero embryonic development; maternal process involved in female pregnancy; chromatin organization; blastocyst hatching;
	Sources:Amigo / QuickGO
Orthologs
	7319
	22209
	ENSG00000077721
	ENSMUSG00000016308
	P49459
	Q9Z255
	NM_181777; NM_001282161; NM_003336; NM_181762
	NM_019668; NM_001313696
	NP_001269090; NP_003327; NP_861427
	NP_001300625; NP_062642
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.