UBE2J1

UBE2J1
Identifiers
Aliases	UBE2J1, HSPC153, HSPC205, HSU93243, NCUBE-1, NCUBE1, UBC6, Ubc6p, CGI-76, UBC6E, ubiquitin conjugating enzyme E2 J1
External IDs	OMIM: 616175; MGI: 1926245; HomoloGene: 41090; GeneCards: UBE2J1; OMA:UBE2J1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	89,352,722 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	33,052,363 bp
RNA expression pattern
	Top expressed in
	sperm; ; monocyte; ; bone marrow cells; ; parotid gland; ; rectum; ; epithelium of nasopharynx; ; amniotic fluid; ; tonsil; ; appendix; ; lymph node;
	Top expressed in
	seminiferous tubule; ; lacrimal gland; ; ectoderm; ; otic vesicle; ; otic placode; ; saccule; ; facial motor nucleus; ; anterior horn of spinal cord; ; spermatid; ; medial vestibular nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ATP binding; ubiquitin protein ligase binding; ubiquitin protein ligase activity; ubiquitin conjugating enzyme activity;
Cellular component	cytoplasm; membrane; integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum;
Biological process	protein N-linked glycosylation via asparagine; protein ubiquitination; ubiquitin-dependent ERAD pathway; spermatid development; negative regulation of retrograde protein transport, ER to cytosol;
	Sources:Amigo / QuickGO
Orthologs
	51465
	56228
	ENSG00000198833
	ENSMUSG00000028277
	Q9Y385
	Q9JJZ4
	NM_016021
	NM_019586; NM_001355494
	NP_057105
	NP_062532; NP_001342423
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.