UBE2L3

UBE2L3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C4Z, 1FBV, 3SQV, 3SY2, 4Q5E, 4Q5H, 5HPT
Identifiers
Aliases	UBE2L3, E2-F1, L-UBC, UBCH7, UbcM4, ubiquitin conjugating enzyme E2 L3
External IDs	OMIM: 603721; MGI: 109240; HomoloGene: 43226; GeneCards: UBE2L3; OMA:UBE2L3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	21,624,034 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,020,513 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; mucosa of transverse colon; ; C1 segment; ; right frontal lobe; ; islet of Langerhans; ; Brodmann area 9; ; smooth muscle tissue; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	spermatid; ; tail of embryo; ; morula; ; internal carotid artery; ; genital tubercle; ; ventricular zone; ; blastocyst; ; yolk sac; ; spermatocyte; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; transcription coactivator activity; ubiquitin-protein transferase activity; protein binding; ubiquitin-protein transferase activator activity; enzyme binding; ATP binding; ubiquitin protein ligase binding; RNA binding; ubiquitin conjugating enzyme activity;
Cellular component	cytoplasm; ubiquitin ligase complex; extracellular exosome; nucleus; nucleoplasm; cytosol;
Biological process	cell cycle phase transition; cellular response to steroid hormone stimulus; regulation of transcription, DNA-templated; ubiquitin-dependent protein catabolic process; positive regulation of protein targeting to mitochondrion; protein polyubiquitination; transcription, DNA-templated; protein K11-linked ubiquitination; cellular response to glucocorticoid stimulus; positive regulation of ubiquitin-protein transferase activity; cell population proliferation; positive regulation of protein ubiquitination; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	7332
	22195
	ENSG00000185651
	ENSMUSG00000038965
	P68036
	P68037
	NM_001256355; NM_001256356; NM_003347; NM_198157
	NM_009456
	NP_001243284; NP_001243285; NP_003338; NP_003338.1
	NP_033482
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 L3 (UBE2L3), also called UBCH7, is a protein that in humans is encoded by the UBE2L3 gene. As an E2 enzyme, UBE2L3 participates in ubiquitination to target proteins for degradation. The role of UBE2L3 in the ubiquitination of the NF-κB precursor implicated it in various major autoimmune diseases, including rheumatoid arthritis (RA), celiac disease, Crohn's disease (CD), and systemic lupus erythematosus.