UBE2Z

UBE2Z
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5A4P
Identifiers
Aliases	UBE2Z, USE1, HOYS7, ubiquitin conjugating enzyme E2 Z
External IDs	OMIM: 611362; MGI: 1343160; HomoloGene: 11319; GeneCards: UBE2Z; OMA:UBE2Z - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,929,056 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,956,214 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; stromal cell of endometrium; ; cartilage tissue; ; corpus epididymis; ; mucosa of ileum; ; smooth muscle tissue; ; beta cell; ; granulocyte; ; nipple; ; lymph node;
	Top expressed in
	choroid plexus of fourth ventricle; ; corneal stroma; ; saccule; ; ectoderm; ; otic placode; ; otic vesicle; ; Gonadal ridge; ; somite; ; endocardial cushion; ; lactiferous gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein binding; ATP binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; ubiquitin protein ligase activity; cysteine-type endopeptidase inhibitor activity;
Cellular component	nucleoplasm; cytoplasm; cytosol; nucleus;
Biological process	apoptotic process; protein ubiquitination; positive regulation of apoptotic process; ubiquitin-dependent protein catabolic process; negative regulation of endopeptidase activity; negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	65264
	268470
	ENSG00000159202
	ENSMUSG00000014349
	Q9H832
	Q3UE37
	NM_023079
	NM_172300
	NP_075567
	NP_758504
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin conjugating enzyme E2 Z (UBE2Z), also known as UBA6-specific E2 enzyme 1 (USE1), is an enzyme that in humans is encoded by the UBE2Z gene on chromosome 17. It is ubiquitously expressed in many tissues and cell types. UBE2Z is an E2 ubiquitin conjugating enzyme and participates in the second step of protein ubiquitination during proteolysis. A genome-wide association study (GWAS) revealed the UBE2Z gene to be associated with chronic kidney disease. The UBE2Z gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.