Ubiquitin-protein ligase E3B

UBE3B
Identifiers
Aliases	UBE3B, BPIDS, KOS, ubiquitin protein ligase E3B
External IDs	OMIM: 608047; MGI: 1891295; HomoloGene: 13775; GeneCards: UBE3B; OMA:UBE3B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	109,536,705 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	114,559,230 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; frontal pole; ; endothelial cell; ; Brodmann area 10; ; paraflocculus of cerebellum; ; muscle of thigh; ; stromal cell of endometrium; ; gastrocnemius muscle; ; left ventricle;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; ankle; ; skeletal muscle tissue; ; vastus lateralis muscle; ; interventricular septum; ; temporal muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; medial head of gastrocnemius muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; ubiquitin-protein transferase activity; ubiquitin protein ligase activity; ubiquitin conjugating enzyme activity;
Cellular component	cytoplasm;
Biological process	protein ubiquitination; protein polyubiquitination; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	89910
	117146
	ENSG00000151148
	ENSMUSG00000029577
	Q7Z3V4
	Q9ES34
NM_001270449; NM_001270450; NM_001270451; NM_130466; NM_183414;
	NM_183415
	NM_054093; NM_001331219
	NP_001257378; NP_001257379; NP_001257380; NP_569733; NP_904324
	NP_001318148; NP_473434
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-Protein Ligase E3B (UBE3B) is an enzyme encoded by UBE3B gene in humans. UBE3B has an N-terminal IQ motif, which mediates calcium-independent calmodulin binding and a large C-terminal catalytic HECT domain.