UBR5

UBR5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I2T, 2QHO, 3PT3
Identifiers
Aliases	UBR5, DD5, EDD, EDD1, HYD, ubiquitin protein ligase E3 component n-recognin 5
External IDs	OMIM: 608413; MGI: 1918040; HomoloGene: 9295; GeneCards: UBR5; OMA:UBR5 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	102,412,759 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	38,079,098 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; sural nerve; ; ganglionic eminence; ; epithelium of colon; ; Achilles tendon; ; left testis; ; gastric mucosa; ; right testis; ; skin of abdomen; ; skin of leg;
	Top expressed in
	genital tubercle; ; tail of embryo; ; saccule; ; spermatocyte; ; neural layer of retina; ; otic placode; ; spermatid; ; otic vesicle; ; cumulus cell; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; ubiquitin binding; protein binding; RNA binding; zinc ion binding; metal ion binding; transferase activity; ubiquitin protein ligase activity;
Cellular component	nucleus; nucleoplasm; membrane; cytosol; perinuclear region of cytoplasm; protein-containing complex;
Biological process	negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; protein polyubiquitination; progesterone receptor signaling pathway; cellular response to DNA damage stimulus; ubiquitin-dependent protein catabolic process; positive regulation of canonical Wnt signaling pathway; protein ubiquitination; cell population proliferation; DNA repair; positive regulation of gene expression; viral process; protein K48-linked ubiquitination; positive regulation of protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	51366
	70790
	ENSG00000104517
	ENSMUSG00000037487
	O95071
	Q80TP3
	NM_001282873; NM_015902
	NM_001081359; NM_001112721; NM_027553
	NP_001269802; NP_056986
	NP_001074828; NP_001106192
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.