UDP-glucose 6-dehydrogenase

UGDH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q3E, 2QG4, 3ITK, 3KHU, 3PRJ, 3PTZ, 3TDK, 3TF5, 4EDF, 4QEJ, 4RJT
Identifiers
Aliases	UGDH, GDH, UDP-GlcDH, UDPGDH, UGD, UDP-glucose 6-dehydrogenase, EIEE84, DEE84
External IDs	OMIM: 603370; MGI: 1306785; HomoloGene: 2520; GeneCards: UGDH; OMA:UGDH - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	39,528,311 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	65,593,292 bp
RNA expression pattern
	Top expressed in
	mucosa of colon; ; mucosa of sigmoid colon; ; islet of Langerhans; ; mucosa of transverse colon; ; vena cava; ; rectum; ; mucosa of ileum; ; decidua; ; bronchial epithelial cell; ; liver;
	Top expressed in
	olfactory epithelium; ; upper arm; ; colon; ; autopod region; ; hand; ; stomach; ; duodenum; ; epidermis; ; proximal tubule; ; metanephros;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD binding; catalytic activity; oxidoreductase activity; electron transfer activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; UDP-glucose 6-dehydrogenase activity;
Cellular component	nucleoplasm; extracellular exosome; nucleus; cytosol;
Biological process	UDP-glucuronate biosynthetic process; gastrulation with mouth forming second; metabolism; UDP-glucose metabolic process; glycosaminoglycan biosynthetic process; electron transport chain; heparan sulfate proteoglycan biosynthetic process; chondroitin sulfate biosynthetic process; protein hexamerization; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	7358
	22235
	ENSG00000109814
	ENSMUSG00000029201
	O60701
	O70475
	NM_001184700; NM_001184701; NM_003359
	NM_009466
	NP_001171629; NP_001171630; NP_003350
	NP_033492
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucose 6-dehydrogenase is a cytosolic enzyme that in humans is encoded by the UGDH gene.

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.

This enzyme participates in 4 metabolic pathways: pentose and glucuronate interconversions, ascorbate and aldarate metabolism, starch and sucrose metabolism, and nucleotide sugars metabolism.

Loss of UGDH has recently been implicated in epileptic encephalopathy in humans