UDP glucuronosyltransferase 1 family, polypeptide A1

UGT1A1
Identifiers
Aliases	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A, UDP glucuronosyltransferase family 1 member A1
External IDs	OMIM: 191740; MGI: 98898; HomoloGene: 128034; GeneCards: UGT1A1; OMA:UGT1A1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,719 bp
RNA expression pattern
	Top expressed in
	duodenum; ; right lobe of liver; ; testicle; ; mucosa of transverse colon; ; human kidney; ; rectum; ; urinary bladder; ; renal cortex; ; gallbladder; ; olfactory zone of nasal mucosa;
	Top expressed in
	duodenum; ; jejunum; ; ileum; ; lip; ; colon; ; hepatobiliary system; ; liver; ; vasculature of organ; ; zone of skin; ; ventricular system;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; enzyme inhibitor activity; retinoic acid binding; hexosyltransferase activity; protein homodimerization activity; glycosyltransferase activity; steroid binding; protein heterodimerization activity; enzyme binding; glucuronosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; integral component of plasma membrane; cytochrome complex; endoplasmic reticulum chaperone complex; endoplasmic reticulum;
Biological process	steroid metabolic process; response to organic cyclic compound; cellular response to ethanol; estrogen metabolic process; response to nutrient; negative regulation of steroid metabolic process; bilirubin conjugation; response to steroid hormone; response to glucocorticoid; retinoic acid metabolic process; negative regulation of cellular glucuronidation; response to organic substance; response to lipopolysaccharide; cellular response to hormone stimulus; heme catabolic process; cellular response to glucocorticoid stimulus; acute-phase response; heterocycle metabolic process; animal organ regeneration; response to starvation; flavone metabolic process; liver development; metabolism; negative regulation of glucuronosyltransferase activity; response to ethanol; negative regulation of fatty acid metabolic process; biphenyl catabolic process; cellular response to estradiol stimulus; flavonoid glucuronidation; cellular glucuronidation; xenobiotic glucuronidation; cellular response to xenobiotic stimulus; negative regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	54658
	394436
	ENSG00000241635
	ENSMUSG00000089960
	P22309
	Q63886
	NM_000463
	NM_201645
	NP_000454
	NP_964007
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 1-1, also known as UGT-1A, is an enzyme that in humans is encoded by the UGT1A1 gene.

UGT-1A is a uridine diphosphate glucuronosyltransferase (UDP-glucuronosyltransferase, UDPGT or UGT), an enzyme of the glucuronidation pathway that transforms small lipophilic (fat-soluble) molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.