UHRF2

UHRF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WY8, 1Z6U, 2E6S, 3OLN, 4PW5, 4PW6, 4PW7, 4TVR
Identifiers
Aliases	UHRF2, NIRF, RNF107, URF2, TDRD23, ubiquitin like with PHD and ring finger domains 2
External IDs	OMIM: 615211; MGI: 1923718; HomoloGene: 17001; GeneCards: UHRF2; OMA:UHRF2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	6,507,054 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	30,071,122 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pancreatic epithelial cell; ; Achilles tendon; ; tibia; ; thymus; ; sperm; ; ventricular zone; ; germinal epithelium; ; bone marrow; ; bone marrow cells;
	Top expressed in
	superior cervical ganglion; ; hand; ; tail of embryo; ; ventricular zone; ; genital tubercle; ; primitive streak; ; lens; ; neural layer of retina; ; epiblast; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; histone binding; protein binding; metal ion binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; transferase activity; SUMO transferase activity;
Cellular component	nucleus; nucleoplasm;
Biological process	protein autoubiquitination; regulation of DNA methylation-dependent heterochromatin assembly; cell cycle; cell differentiation; cell population proliferation; maintenance of DNA methylation; protein ubiquitination; regulation of cell cycle; protein sumoylation;
	Sources:Amigo / QuickGO
Orthologs
	115426
	109113
	ENSG00000147854
	ENSMUSG00000024817
	Q96PU4
	Q7TMI3
	NM_152896; NM_152306
	NM_144873
	NP_690856
	NP_659122
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.