ULK1

ULK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WNO, 4WNP, 5CI7
Identifiers
Aliases	ULK1, ATG1, ATG1A, UNC51, Unc51.1, hATG1, unc-51 like autophagy activating kinase 1
External IDs	OMIM: 603168; MGI: 1270126; HomoloGene: 2640; GeneCards: ULK1; OMA:ULK1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	131,923,150 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	110,957,963 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; left ovary; ; right hemisphere of cerebellum; ; gastrocnemius muscle; ; skin of leg; ; anterior pituitary; ; gastric mucosa; ; right ovary; ; middle frontal gyrus; ; nucleus accumbens;
	Top expressed in
	muscle of thigh; ; genital tubercle; ; granulocyte; ; lip; ; cardiac muscle tissue of left ventricle; ; cerebellar cortex; ; tail of embryo; ; ganglionic eminence; ; medial head of gastrocnemius muscle; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; kinase activity; GTPase binding; identical protein binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; phagophore assembly site membrane; extrinsic component of omegasome membrane; Atg1/ULK1 kinase complex; extrinsic component of phagophore assembly site membrane; phagophore assembly site; autophagosome; extrinsic component of autophagosome membrane; endoplasmic reticulum membrane; recycling endosome; guanyl-nucleotide exchange factor complex; mitochondrial outer membrane; axon; membrane;
Biological process	neuron projection regeneration; protein localization; axonogenesis; phosphorylation; negative regulation of protein-containing complex assembly; protein phosphorylation; peptidyl-serine phosphorylation; cellular response to nutrient levels; axon extension; response to starvation; protein autophosphorylation; neuron projection development; signal transduction; autophagy; macroautophagy; peptidyl-threonine phosphorylation; regulation of macroautophagy; positive regulation of autophagosome assembly; autophagosome assembly; regulation of autophagy; positive regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
	8408
	22241
	ENSG00000177169
	ENSMUSG00000029512
	O75385
	O70405
	NM_003565
	NM_009469; NM_001347394
	NP_003556
	NP_001334323; NP_033495
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.

Unc-51-like autophagy-activating kinases 1 and 2 (ULK1/2) are two similar isoforms of an enzyme that in humans is encoded by the ULK1/2 genes. The enzyme is specifically a kinase that is involved with autophagy, particularly in response to amino acid withdrawal. Not many studies have been done comparing the two isoforms, but some differences have been recorded.