Uncoordinated-119 (Unc-119)

UNC119
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3GQQ, 3RBQ, 4GOJ, 4GOK
Identifiers
Aliases	UNC119, HRG4, IMD13, POC7, POC7A, Protein unc-119 homolog, unc-119 lipid binding chaperone
External IDs	MGI: 1328357; HomoloGene: 3778; GeneCards: UNC119; OMA:UNC119 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,552,631 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,239,990 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right testis; ; left testis; ; right frontal lobe; ; right hemisphere of cerebellum; ; spleen; ; cingulate gyrus; ; anterior cingulate cortex; ; blood;
	Top expressed in
	neural layer of retina; ; retinal pigment epithelium; ; granulocyte; ; epithelium of lens; ; choroid plexus of fourth ventricle; ; ventricular zone; ; pineal gland; ; ciliary body; ; left colon; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lipid binding; protein binding;
Cellular component	cytoplasm; cytosol; centrosome; spindle pole; spindle; microtubule organizing center; intercellular bridge; spindle midzone; cytoskeleton;
Biological process	endocytosis; response to stimulus; positive regulation of protein tyrosine kinase activity; protein transport; visual perception; phototransduction; chemical synaptic transmission; neuron differentiation; lipoprotein transport; negative regulation of clathrin-dependent endocytosis; negative regulation of caveolin-mediated endocytosis; mitotic cytokinesis; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	9094
	22248
	ENSG00000109103
	ENSMUSG00000002058
	Q13432
	Q9Z2R6
	NM_005148; NM_054035; NM_001330166
	NM_011676; NM_001313985; NM_001313986; NM_001313987; NM_001313988
	NP_001317095; NP_005139; NP_473376
	NP_001300914; NP_001300915; NP_001300916; NP_001300917; NP_035806
	Wikidata
View/Edit Human	View/Edit Mouse

Uncoordinated-119 (Unc-119) is a protein identified in a varieties of species including, C. elegans, humans, mice, zebrafish, rabbits, pig, calf, monkey, and protozoa. This proteins have been classified in the GMP phosphodiesterase, delta superfamily. Although Unc-119 proteins are categorized into their own family, they are shown to be ancestrally related to PrBP (prenyl binding protein) and rhoGDI. They are also known by several other names: Retinal Protein 4, HRG4, POC7 Centriolar Protein Homolog A, IMD13, POC7A, and RG4.