Uracil-DNA glycosylase

UNG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AKZ, 1DPU, 1EMH, 1EMJ, 1Q3F, 1SSP, 1UGH, 1YUO, 2HXM, 2OXM, 2OYT, 2SSP, 3FCF, 3FCI, 3FCK, 3FCL, 3TKB, 4SKN, 5AYR
Identifiers
Aliases	UNG, DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2, uracil DNA glycosylase
External IDs	OMIM: 191525; MGI: 109352; HomoloGene: 6585; GeneCards: UNG; OMA:UNG - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	109,110,992 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	114,277,384 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right adrenal cortex; ; ventricular zone; ; embryo; ; left adrenal gland; ; renal medulla; ; ganglionic eminence; ; left adrenal cortex; ; gonad; ; mucosa of transverse colon;
	Top expressed in
	Paneth cell; ; primitive streak; ; primary oocyte; ; ureter; ; zygote; ; secondary oocyte; ; renal corpuscle; ; medullary collecting duct; ; condyle; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	damaged DNA binding; protein binding; hydrolase activity; hydrolase activity, hydrolyzing N-glycosyl compounds; ribosomal small subunit binding; uracil DNA N-glycosylase activity;
Cellular component	nucleus; mitochondrion; nucleoplasm;
Biological process	positive regulation of isotype switching; somatic hypermutation of immunoglobulin genes; viral process; negative regulation of apoptotic process; depyrimidination; DNA repair; somatic recombination of immunoglobulin gene segments; cellular response to DNA damage stimulus; base-excision repair, AP site formation via deaminated base removal; base-excision repair; isotype switching;
	Sources:Amigo / QuickGO
Orthologs
	7374
	22256
	ENSG00000076248
	ENSMUSG00000029591
	P13051
	P97931
	NM_080911; NM_003362
	NM_001040691; NM_011677
	NP_003353; NP_550433
	NP_001035781; NP_035807
	Wikidata
View/Edit Human	View/Edit Mouse

Uracil-DNA glycosylase (also known as UNG or UDG) is an enzyme. Its most important function is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosidic bond and initiating the base-excision repair (BER) pathway.