UPF3B

UPF3B
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1UW4, 2XB2
Identifiers
Aliases	UPF3B, HMRX62, MRXS14, RENT3B, UPF3X, Upf3p-X, UPF3BP1, UPF3BP2, UPF3BP3, UPF3 regulator of nonsense transcripts homolog B (yeast), UPF3 regulator of nonsense transcripts homolog B, regulator of nonsense mediated mRNA decay, UPF3B regulator of nonsense mediated mRNA decay, MRX82
External IDs	OMIM: 300298; MGI: 1915384; HomoloGene: 11307; GeneCards: UPF3B; OMA:UPF3B - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	119,852,998 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	37,110,322 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; embryo; ; cerebellar hemisphere; ; ganglionic eminence; ; endothelial cell; ; amniotic fluid; ; right hemisphere of cerebellum; ; ventricular zone; ; testicle; ; visceral pleura;
	Top expressed in
	Ileal epithelium; ; Paneth cell; ; neural layer of retina; ; pineal gland; ; medullary collecting duct; ; retinal pigment epithelium; ; epithelium of lens; ; islet of Langerhans; ; fossa; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; mRNA binding; structural constituent of nuclear pore; nucleic acid binding; RNA binding;
Cellular component	exon-exon junction complex; nucleoplasm; microtubule organizing center; nucleolus; nucleus; cytoplasm; cytosol;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA transport; mRNA export from nucleus; positive regulation of translation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA 3'-end processing; RNA export from nucleus; transport;
	Sources:Amigo / QuickGO
Orthologs
	65109
	68134
	ENSG00000125351
	ENSMUSG00000036572
	Q9BZI7
	n/a
	NM_023010; NM_080632
	NM_026573
	NP_075386; NP_542199
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of nonsense transcripts 3B is a protein that in humans is encoded by the UPF3B gene.

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.