United States Interregional Soccer League
| Promotional poster for the 1994 season | |
| Organising body | USISL | 
|---|---|
| First season | 1989 | 
| Folded | 1994 | 
| Replaced by | |
| Country | United States | 
| Confederation | CONCACAF | 
| Number of clubs | 69 (1994) | 
| Level on pyramid | Division 3 (1994) | 
| Most championships | 
 | 
The United States Interregional Soccer League (USISL) was a semi-professional men's outdoor soccer league that played six seasons from 1989 to 1994. It was the first outdoor league to be operated by the organization known today as the United Soccer League. Commencing play in 1989, it received Division 3 status from U.S. Soccer for its final season in 1994. It was split into the USISL Professional League and the amateur USISL Premier League in 1995. The Colorado Comets and Greensboro Dynamo were the most successful clubs in the league, winning two championships each.