USP1

USP1
Identifiers
Aliases	USP1, UBP, ubiquitin specific peptidase 1
External IDs	OMIM: 603478; MGI: 2385198; HomoloGene: 2528; GeneCards: USP1; OMA:USP1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	62,451,804 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	98,823,780 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; sperm; ; trabecular bone; ; ganglionic eminence; ; gonad; ; endothelial cell; ; germinal epithelium; ; cartilage tissue; ; tibia;
	Top expressed in
	seminiferous tubule; ; gastrula; ; primitive streak; ; spermatid; ; spermatocyte; ; vas deferens; ; mandibular prominence; ; abdominal wall; ; ureter; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; protein binding; hydrolase activity; thiol-dependent deubiquitinase; cysteine-type endopeptidase activity; peptidase activity;
Cellular component	nucleus; nucleoplasm;
Biological process	skeletal system development; monoubiquitinated protein deubiquitination; response to UV; ubiquitin-dependent protein catabolic process; proteolysis; cellular response to DNA damage stimulus; protein deubiquitination; DNA repair; regulation of DNA repair; interstrand cross-link repair;
	Sources:Amigo / QuickGO
Orthologs
	7398
	230484
	ENSG00000162607
	ENSMUSG00000028560
	O94782
	Q8BJQ2
	NM_003368; NM_001017415; NM_001017416
	NM_001301414; NM_146144; NM_001356424
	NP_001017415; NP_001017416; NP_003359
	NP_001288343; NP_666256; NP_001343353
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.

The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.