USP15

USP15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W6V, 3LMN, 3PPA, 3PV1, 3T9L, 4A3O, 4A3P, 5JJW
Identifiers
Aliases	USP15, UNPH-2, UNPH4, ubiquitin specific peptidase 15
External IDs	OMIM: 604731; MGI: 101857; HomoloGene: 101542; GeneCards: USP15; OMA:USP15 - orthologs
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	123,032,900 bp
Gene ontology
Molecular function	ubiquitin modification-dependent histone binding; cysteine-type peptidase activity; peptidase activity; protein binding; catalytic activity; thiol-dependent deubiquitinase; identical protein binding; transforming growth factor beta receptor binding; cysteine-type endopeptidase activity; SMAD binding; hydrolase activity;
Cellular component	cytoplasm; nucleus; cytosol; mitochondrion;
Biological process	pathway-restricted SMAD protein phosphorylation; ubiquitin-dependent protein catabolic process; monoubiquitinated protein deubiquitination; BMP signaling pathway; proteolysis; histone H2B conserved C-terminal lysine deubiquitination; transforming growth factor beta receptor signaling pathway; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	9958
	14479
	ENSG00000135655
	ENSMUSG00000020124
	Q9Y4E8
	Q8R5H1
	NM_001252078; NM_001252079; NM_006313
	NM_001301628; NM_027604
NP_001239007; NP_001239008; NP_006304; NP_001338088; NP_001338089;
	NP_001338090; NP_001338091; NP_001338092; NP_001338093; NP_001338094; NP_001338095
	NP_001288557; NP_081880
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene.

Ubiquitin is a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, which is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).