USP16

USP16
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I50
Identifiers
Aliases	USP16, UBP-M, UBPM, ubiquitin specific peptidase 16
External IDs	OMIM: 604735; MGI: 1921362; HomoloGene: 38183; GeneCards: USP16; OMA:USP16 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	29,054,488 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	87,483,517 bp
RNA expression pattern
	Top expressed in
	oocyte; ; sperm; ; epithelium of nasopharynx; ; Achilles tendon; ; pylorus; ; secondary oocyte; ; epithelium of colon; ; tendon of biceps brachii; ; parietal pleura; ; cardia;
	Top expressed in
	zygote; ; morula; ; tail of embryo; ; genital tubercle; ; spermatid; ; muscle of thigh; ; seminiferous tubule; ; parotid gland; ; soleus muscle; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; zinc ion binding; metal ion binding; peptidase activity; hydrolase activity; transcription coactivator activity; cysteine-type endopeptidase activity; histone binding; ubiquitin binding; thiol-dependent deubiquitinase;
Cellular component	cytoplasm; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; ubiquitin-dependent protein catabolic process; positive regulation of translational elongation; regulation of transcription by RNA polymerase II; monoubiquitinated histone H2A deubiquitination; transcription, DNA-templated; proteolysis; cellular response to DNA damage stimulus; cell division; histone H2A K63-linked deubiquitination; positive regulation of transcription by RNA polymerase II; protein deubiquitination; positive regulation of transcription, DNA-templated; protein homotetramerization; regulation of gene expression; histone deubiquitination; regulation of cell cycle; mitotic cell cycle; chromatin organization; cell cycle; mitotic nuclear division;
	Sources:Amigo / QuickGO
Orthologs
	10600
	74112
	ENSG00000156256
	ENSMUSG00000025616
	Q9Y5T5
	Q99LG0
	NM_006447; NM_001001992; NM_001032410
	NM_024258
	NP_001001992; NP_001027582; NP_006438
	NP_077220
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 16 is an enzyme that in humans is encoded by the USP16 gene.

This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.