USP20

USP20
Identifiers
Aliases	USP20, LSFR3A, VDU2, hVDU2, ubiquitin specific peptidase 20
External IDs	OMIM: 615143; MGI: 1921520; HomoloGene: 4861; GeneCards: USP20; OMA:USP20 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	129,881,828 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	30,913,598 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; anterior pituitary; ; right lobe of thyroid gland; ; right hemisphere of cerebellum; ; left lobe of thyroid gland; ; right frontal lobe; ; ascending aorta; ; gastric mucosa; ; muscle layer of sigmoid colon; ; Descending thoracic aorta;
	Top expressed in
	spermatid; ; lumbar spinal ganglion; ; spermatocyte; ; habenula; ; dentate gyrus of hippocampal formation granule cell; ; dorsomedial hypothalamic nucleus; ; subiculum; ; right kidney; ; paraventricular nucleus of hypothalamus; ; dorsal tegmental nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; zinc ion binding; metal ion binding; peptidase activity; protein binding; thiol-dependent deubiquitinase; cysteine-type endopeptidase activity; hydrolase activity; G protein-coupled receptor binding;
Cellular component	cytoplasm; centrosome; microtubule organizing center; perinuclear region of cytoplasm; cytoskeleton; cytosol;
Biological process	endocytosis; protein K48-linked deubiquitination; ubiquitin-dependent protein catabolic process; regulation of G protein-coupled receptor signaling pathway; proteolysis; protein K63-linked deubiquitination; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	10868
	74270
	ENSG00000136878
	ENSMUSG00000026854
	Q9Y2K6
	Q8C6M1
	NM_001008563; NM_001110303; NM_006676
	NM_028846
	NP_001008563; NP_001103773; NP_006667
	NP_083122
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 20 is an enzyme that in humans is encoded by the USP20 gene.

Ubiquitin-specific protease 20 (USP20), also known as ubiquitin-binding protein 20 and VHL protein-interacting deubiquitinating enzyme 2 (VDU2), is a cysteine protease deubiquitinating enzyme (DUB). The catalytic site of USP20, like other DUBs, contains conserved cysteine and histidine residues that catalyse the proteolysis of an isopeptide bond between a lysine residue of a target protein and a glycine residue of a ubiquitin molecule. USP20 is known to deubiquitinate a number of proteins including thyronine deiodinase type 2 (D2), Hypoxia-inducible factor 1α (HIF1α), and β₂ adrenergic receptor (β₂AR).