USP9Y

USP9Y
Identifiers
Aliases	USP9Y, DFFRY, SPGFY2, ubiquitin specific peptidase 9, Y-linked, ubiquitin specific peptidase 9 Y-linked
External IDs	OMIM: 400005; MGI: 1313274; HomoloGene: 68408; GeneCards: USP9Y; OMA:USP9Y - orthologs
Gene location (Human)
Chr.	Y chromosome (human)
End	12,860,839 bp
Gene location (Mouse)
Chr.	Y chromosome (mouse)
End	1,459,782 bp
RNA expression pattern
	Top expressed in
	testicle; ; right lung; ; Brodmann area 9; ; prostate; ; gonad; ; skin of thigh; ; seminal vesicula; ; apex of heart; ; corpus epididymis; ; right hemisphere of cerebellum;
	Top expressed in
	spermatid; ; embryo; ; seminiferous tubule; ; spermatocyte; ; Gonadal ridge; ; left lung lobe; ; trachea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiol-dependent deubiquitinase; peptidase activity; cysteine-type peptidase activity; co-SMAD binding; hydrolase activity; cysteine-type endopeptidase activity;
Cellular component	cytoplasm;
Biological process	protein deubiquitination; transforming growth factor beta receptor signaling pathway; cell migration; BMP signaling pathway; ubiquitin-dependent protein catabolic process; spermatogenesis; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	8287
	107868
	ENSG00000114374
	ENSMUSG00000069044
	O00507
	F8VPU6
	NM_004654
	NM_148943
	NP_004645
	NP_683745
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila), also known as USP9Y, is an enzyme which in humans is encoded by the USP9Y gene. It is required for sperm production. This enzyme is a member of the peptidase C19 family and is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.