Urotensin-II

Urotensin-II
Names
	IUPAC name L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine (5→10)-disulfide
Identifiers
CAS Number	251293-28-4;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL437430;
ChemSpider	24646295;
PubChem CID	146158369;
	InChI InChI=1S/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+/m1/s1 Key: HFNHAPQMXICKCF-USJMABIRSA-N; InChI=1/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+/m1/s1 Key: HFNHAPQMXICKCF-USJMABIRBM;
	SMILES C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)Cc3ccccc3)Cc4c[nH]c5c4cccc5)CCCCN)Cc6ccc(cc6)O)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](CCC(=O)O)N)O;
Properties
Chemical formula	C64H85N13O18S2
Molar mass	1388.6 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

UTS2
Identifiers
Aliases	UTS2, PRO1068, U-II, UCN2, UII, urotensin 2
External IDs	OMIM: 604097; MGI: 1346329; HomoloGene: 4939; GeneCards: UTS2; OMA:UTS2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	7,853,512 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	151,086,267 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; right adrenal cortex; ; granulocyte; ; lymph node; ; left adrenal cortex; ; rectum; ; epithelium of colon; ; mononuclear cell; ; mucosa of transverse colon;
	Top expressed in
	lumbar subsegment of spinal cord; ; facial motor nucleus; ; anterior horn of spinal cord; ; motor neuron; ; neural layer of retina; ; cerebellar cortex; ; spermatid; ; neural tube; ; skeletal muscle tissue; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hormone activity; signaling receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	muscle contraction; regulation of blood pressure; chemical synaptic transmission; blood vessel diameter maintenance; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10911
	24111
	ENSG00000049247
	ENSMUSG00000028963
	O95399
	Q9QZQ3
	NM_006786; NM_021995
	NM_011910
	NP_006777; NP_068835
	NP_036040
	Wikidata
View/Edit Human	View/Edit Mouse

Urotensin-II (U-II) is a peptide ligand that is the strongest known vasoconstrictor. Because of the involvement of the UII system in multiple biological systems such as the cardiovascular, nervous, endocrine, and renal, it represents a promising target for the development of new drugs.

In humans, Urotensin-2 is encoded by the UTS2 gene.