UTY (gene)

UTY
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3ZLI, 3ZPO, 4UF0, 5FY0, 5FXW, 5FXX, 5FXZ, 5FY1, 5FY7, 5FYM, 5FXV, 5A1L
Identifiers
Aliases	UTY, KDM6AL, UTY1, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, KDM6C
External IDs	OMIM: 400009; GeneCards: UTY; OMA:UTY - orthologs
Gene location (Human)
Chr.	Y chromosome (human)
End	13,480,673 bp
RNA expression pattern
	Top expressed in
	gonad; ; corpus callosum; ; testicle; ; tendon of biceps brachii; ; rectum; ; right lung; ; prostate; ; cartilage tissue; ; corpus epididymis; ; middle frontal gyrus;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; dioxygenase activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; metal ion binding; histone demethylase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; chromatin DNA binding; sequence-specific DNA binding;
Cellular component	nucleus; nucleoplasm; MLL3/4 complex;
Biological process	regulation of gene expression; histone H3-K27 demethylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	7404
	n/a
	ENSG00000183878
	n/a
	O14607
	n/a
NM_001258249; NM_001258250; NM_001258251; NM_001258252; NM_001258253;
	NM_001258254; NM_001258255; NM_001258256; NM_001258257; NM_001258258; NM_001258259; NM_001258260; NM_001258261; NM_001258262; NM_001258263; NM_001258264; NM_001258265; NM_001258266; NM_001258267; NM_001258268; NM_001258269; NM_001258270; NM_007125; NM_182659; NM_182660; NM_001400170; NM_001400171; NM_001400173; NM_001400175; NM_001400177; NM_001400178; NM_001400181; NM_001400183; NM_001400185; NM_001400187; NM_001400189; NM_001400192; NM_001400195; NM_001400199
	n/a
NP_001245178; NP_001245179; NP_001245180; NP_001245181; NP_001245182;
	NP_001245183; NP_001245184; NP_001245185; NP_001245186; NP_001245187; NP_001245188; NP_001245189; NP_001245190; NP_001245191; NP_001245192; NP_001245193; NP_001245194; NP_001245195; NP_001245196; NP_001245197; NP_001245198; NP_001245199; NP_009056; NP_872600; NP_872601; NP_001245196.1; NP_001245192.1; NP_001245178.1; NP_001245194.1; NP_001245186.1; NP_001245191.1; NP_001245187.1
	n/a
	Wikidata
View/Edit Human

Histone demethylase UTY, or Ubiquitously transcribed tetratricopeptide repeat, Y chromosome, is an enzyme that in humans is encoded by the UTY gene.

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein–protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.

The X-chromosome version of this gene is called UTX.