UVRAG

UVRAG
Identifiers
Aliases	UVRAG, DHTX, VPS38, p63, UV radiation resistance associated
External IDs	OMIM: 602493; MGI: 1925860; HomoloGene: 31150; GeneCards: UVRAG; OMA:UVRAG - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	76,144,232 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,790,348 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Achilles tendon; ; subcutaneous adipose tissue; ; epithelium of colon; ; abdominal fat; ; monocyte; ; parietal pleura; ; lymph node; ; tonsil; ; testicle;
	Top expressed in
	gastrula; ; primary oocyte; ; zygote; ; calvaria; ; spleen; ; stroma of bone marrow; ; secondary oocyte; ; decidua; ; thymus; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding; SNARE binding;
Cellular component	cytoplasm; HOPS complex; endosome; late endosome; centrosome; chromosome; midbody; early endosome; phagocytic vesicle; endoplasmic reticulum; DNA-dependent protein kinase complex; lysosome; chromosome, centromeric region; protein-containing complex; autophagosome membrane; autophagosome; cytoplasmic vesicle;
Biological process	double-strand break repair via classical nonhomologous end joining; regulation of cytokinesis; regulation of protein serine/threonine kinase activity; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; multivesicular body sorting pathway; chromosome segregation; regulation of vesicle-mediated transport; receptor catabolic process; cellular response to DNA damage stimulus; autophagy; spindle organization; viral entry into host cell; maintenance of Golgi location; DNA repair; SNARE complex assembly; positive regulation of autophagosome maturation; centrosome cycle; autophagosome maturation;
	Sources:Amigo / QuickGO
Orthologs
	7405
	78610
	ENSG00000198382
	ENSMUSG00000035354
	Q9P2Y5
	Q8K245
	NM_003369
	NM_178635
	NP_003360
	NP_848750
	Wikidata
View/Edit Human	View/Edit Mouse

UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells.

Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.