UXS1

UXS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B69, 4GLL, 4LK3, 4M55
Identifiers
Aliases	UXS1, SDR6E1, UGD, UDP-glucuronate decarboxylase 1
External IDs	OMIM: 609749; MGI: 1915133; HomoloGene: 41609; GeneCards: UXS1; OMA:UXS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	106,194,301 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	43,827,800 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; renal medulla; ; cartilage tissue; ; tibia; ; visceral pleura; ; decidua; ; germinal epithelium; ; spinal ganglia; ; trigeminal ganglion; ; stromal cell of endometrium;
	Top expressed in
	decidua; ; motor neuron; ; Epithelium of choroid plexus; ; primary oocyte; ; fossa; ; condyle; ; endothelial cell of lymphatic vessel; ; cumulus cell; ; secondary oocyte; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; carboxy-lyase activity; NAD+ binding; lyase activity; UDP-glucuronate decarboxylase activity;
Cellular component	integral component of membrane; Golgi cisterna membrane; Golgi apparatus; extracellular exosome; mitochondrion; membrane; cytoplasm;
Biological process	protein tetramerization; UDP-D-xylose biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	80146
	67883
	ENSG00000115652
	ENSMUSG00000057363
	Q8NBZ7
	Q91XL3
NM_001253875; NM_001253876; NM_025076; NM_001377504; NM_001377505;
	NM_001377506; NM_001377507; NM_001377508; NM_001377509
	NM_026430
NP_001240804; NP_001240805; NP_079352; NP_001364433; NP_001364434;
	NP_001364435; NP_001364436; NP_001364437; NP_001364438
	NP_080706; NP_001355216; NP_001355217; NP_001355218
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronic acid decarboxylase 1 is an enzyme that in humans is encoded by the UXS1 gene.

UDP-glucuronate decarboxylase (UGD; EC 4.1.1.35) catalyzes the formation of UDP-xylose from UDP-glucuronate. UDP-xylose is then used to initiate glycosaminoglycan biosynthesis on the core protein of proteoglycans.[supplied by OMIM]