UBQLN1

UBQLN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JY5, 2JY6, 2KLC
Identifiers
Aliases	UBQLN1, DA41, DSK2, PLIC-1, UBQN, XDRP1, ubiquilin 1
External IDs	OMIM: 605046; MGI: 1860276; HomoloGene: 137258; GeneCards: UBQLN1; OMA:UBQLN1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	83,707,958 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	58,363,467 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; cardiac muscle tissue of right atrium; ; skin of arm; ; tibialis anterior muscle; ; myocardium of left ventricle; ; endothelial cell; ; Pons; ; pancreatic epithelial cell; ; ganglionic eminence; ; stromal cell of endometrium;
	Top expressed in
	secondary oocyte; ; seminal vesicula; ; parotid gland; ; medial dorsal nucleus; ; pontine nuclei; ; ventral tegmental area; ; dorsal tegmental nucleus; ; deep cerebellar nuclei; ; primitive streak; ; medial geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	polyubiquitin modification-dependent protein binding; kinase binding; protein binding; identical protein binding;
Cellular component	cytoplasm; membrane; plasma membrane; nucleoplasm; aggresome; autophagosome; endoplasmic reticulum; perinuclear region of cytoplasm; proteasome complex; cytoplasmic vesicle; nucleus; cytosol; protein-containing complex;
Biological process	aggrephagy; negative regulation of store-operated calcium channel activity; regulation of protein ubiquitination; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; response to endoplasmic reticulum stress; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; autophagy; ubiquitin-dependent ERAD pathway; positive regulation of protein ubiquitination; negative regulation of toll-like receptor 3 signaling pathway; cellular response to hypoxia; autophagosome maturation; autophagosome assembly; macroautophagy; ubiquitin-dependent protein catabolic process; regulation of macroautophagy;
	Sources:Amigo / QuickGO
Orthologs
	29979
	56085
	ENSG00000135018
	ENSMUSG00000005312
	Q9UMX0
	Q8R317
	NM_013438; NM_053067
	NM_026842; NM_152234
	NP_038466; NP_444295; NP_444295.1
	NP_081118; NP_689420
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.

Ubiquilins contain two domains, an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation.