Ubiquitin-activating enzyme
| Ubiquitin-activating enzymes | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Crystal structure of the yeast ubiquitin-activating enzyme E1 / ubiquitin complex. | |||||||||
| Identifiers | |||||||||
| EC no. | 6.2.1.45 | ||||||||
| CAS no. | 74812-49-0 | ||||||||
| Alt. names | E1 enzymes | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. This covalent bond of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Many processes such as cell division, immune responses and embryonic development are also regulated by post-translational modification by ubiquitin and ubiquitin-like proteins.