Ubiquitin C

UBC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C3T, 1CMX, 1D3Z, 1F9J, 1FXT, 1G6J, 1GJZ, 1NBF, 1OGW, 1Q5W, 1S1Q, 1SIF, 1TBE, 1UBI, 1UBQ, 1UD7, 1XD3, 1XQQ, 1YX5, 1YX6, 1ZGU, 2AYO, 2BGF, 2DEN, 2FUH, 2G45, 2GBJ, 2GBK, 2GBM, 2GBN, 2GBR, 2GMI, 2HTH, 2IBI, 2J7Q, 2JF5, 2JRI, 2JY6, 2JZZ, 2K25, 2K6D, 2K8B, 2K8C, 2KDF, 2KJH, 2KLG, 2KN5, 2KX0, 2L3Z, 2LD9, 2LVO, 2LVP, 2LVQ, 2LZ6, 2MBO, 2MBQ, 2MCN, 2MI8, 2MJ5, 2MOR, 2MRE, 2MWS, 2N2K, 2NR2, 2O6V, 2OJR, 2PE9, 2PEA, 2RR9, 2RU6, 2W9N, 2WDT, 2XEW, 2Z59, 2ZCB, 2ZVN, 2ZVO, 3A33, 3ALB, 3AUL, 3B08, 3B0A, 3BY4, 3C0R, 3DVG, 3DVN, 3EEC, 3EFU, 3EHV, 3H7P, 3H7S, 3HM3, 3IFW, 3IHP, 3JSV, 3JVZ, 3JW0, 3K9O, 3K9P, 3KVF, 3KW5, 3LDZ, 3MHS, 3MTN, 3N30, 3N32, 3N3K, 3NS8, 3O65, 3OFI, 3OJ4, 3ONS, 3PRM, 3PT2, 3PTF, 3Q3F, 3RUL, 3TMP, 3U30, 3UGB, 3V6C, 3V6E, 3VFK, 3VUW, 3VUX, 3VUY, 3WXE, 3WXF, 3ZNI, 3ZNZ, 4AUQ, 4BOS, 4BOZ, 4BVU, 4DDG, 4DDI, 4DHJ, 4DHZ, 4FJV, 4HK2, 4HXD, 4I6L, 4I6N, 4IG7, 4IUM, 4JQW, 4K1R, 4K7S, 4K7U, 4K7W, 4KSK, 4KSL, 4LCD, 4LDT, 4MDK, 4MM3, 4MSM, 4MSQ, 4NQK, 4UN2, 4V3K, 4V3L, 5AIU, 4XOK, 5AF6, 5AF5, 5AF4, 4XOL, 5C7J, 5C7M, 5E6J, 4ZQS, 4AP4,%%s4AP4
Identifiers
Aliases	UBC, HMG20, Ubiquitin C
External IDs	OMIM: 191340; MGI: 98889; HomoloGene: 128418; GeneCards: UBC; OMA:UBC - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	124,917,368 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	125,467,266 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; Brodmann area 46; ; pericardium; ; vena cava; ; cerebellar vermis; ; postcentral gyrus; ; spinal ganglia; ; trigeminal ganglion; ; lateral nuclear group of thalamus; ; frontal pole;
	Top expressed in
	granulocyte; ; right kidney; ; endothelial cell of lymphatic vessel; ; temporal muscle; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; triceps brachii muscle; ; central gray substance of midbrain; ; sternocleidomastoid muscle; ; calvaria;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protease binding; protein binding; RNA binding; protein tag; ubiquitin protein ligase binding;
Cellular component	cytoplasm; endocytic vesicle membrane; cytosol; nucleus; extracellular exosome; plasma membrane; nucleoplasm; endosome membrane; extracellular space; mitochondrial outer membrane; endoplasmic reticulum quality control compartment; vesicle; endoplasmic reticulum membrane; host cell;
Biological process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of epidermal growth factor receptor signaling pathway; interstrand cross-link repair; nucleotide-excision repair, DNA damage recognition; positive regulation of canonical Wnt signaling pathway; tumor necrosis factor-mediated signaling pathway; regulation of type I interferon production; TRIF-dependent toll-like receptor signaling pathway; Fc-epsilon receptor signaling pathway; endosomal transport; global genome nucleotide-excision repair; NIK/NF-kappaB signaling; G2/M transition of mitotic cell cycle; stress-activated MAPK cascade; transforming growth factor beta receptor signaling pathway; macroautophagy; negative regulation of canonical Wnt signaling pathway; nucleotide-excision repair, DNA gap filling; error-free translesion synthesis; regulation of tumor necrosis factor-mediated signaling pathway; stimulatory C-type lectin receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; JNK cascade; regulation of transcription from RNA polymerase II promoter in response to hypoxia; nucleotide-excision repair, DNA incision; I-kappaB kinase/NF-kappaB signaling; innate immune response; Notch signaling pathway; regulation of mRNA stability; protein polyubiquitination; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; virion assembly; positive regulation of NF-kappaB transcription factor activity; anaphase-promoting complex-dependent catabolic process; negative regulation of type I interferon production; nucleotide-binding oligomerization domain containing signaling pathway; intracellular transport of virus; viral life cycle; MyD88-dependent toll-like receptor signaling pathway; error-prone translesion synthesis; MAPK cascade; fibroblast growth factor receptor signaling pathway; ion transmembrane transport; glycogen biosynthetic process; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; translesion synthesis; transcription-coupled nucleotide-excision repair; T cell receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; positive regulation of transcription by RNA polymerase II; nucleotide-excision repair, DNA incision, 5'-to lesion; Wnt signaling pathway; nucleotide-excision repair, DNA duplex unwinding; regulation of signal transduction by p53 class mediator; ERBB2 signaling pathway; nucleotide-excision repair, preincision complex assembly; Wnt signaling pathway, planar cell polarity pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of epidermal growth factor receptor signaling pathway; protein folding; negative regulation of G2/M transition of mitotic cell cycle; protein ubiquitination; protein deubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; entry of bacterium into host cell; transmembrane transport; regulation of necroptotic process; membrane organization; endoplasmic reticulum mannose trimming; cellular iron ion homeostasis; regulation of hematopoietic stem cell differentiation; protein targeting to peroxisome; cytokine-mediated signaling pathway; modification-dependent protein catabolic process; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7316
	22190
	ENSG00000150991
	ENSMUSG00000008348
	P0CG48
	P0CG50
	NM_021009
	NM_019639
	NP_066289
	NP_062613
	Wikidata
View/Edit Human	View/Edit Mouse

Polyubiquitin-C is a protein encoded by the UBC gene in humans. Polyubiquitin-C is one of the sources of ubiquitin, along with UBB, UBA52, and RPS27A.

UBC gene is one of the two stress-regulated polyubiquitin genes (UBB and UBC) in mammals. It plays a key role in maintaining cellular ubiquitin levels under stress conditions. Defects of UBC gene could lead to mid-gestation embryonic lethality.