University of Pennsylvania Health System
| Penn Medicine | |
| Company type | Private hospital network | 
| Industry | Health care | 
| Founded | 1993 in Philadelphia, PA | 
| Headquarters | , | 
| Number of locations | 6 hospitals, 10 multispecialty centers, doctors' offices, clinics & sites | 
| Areas served | Delaware Valley Central Jersey South Central Pennsylvania | 
| Key people | Kevin B. Mahoney (CEO) Jonathan A. Epstein (interim EVP) | 
| Services | Hospital network | 
| Owner | Trustees of the University of Pennsylvania | 
| Website | pennmedicine | 
The University of Pennsylvania Health System (UPHS) is a major multi-hospital health system headquartered in Philadelphia, Pennsylvania. UPHS and the Perelman School of Medicine at the University of Pennsylvania together comprise Penn Medicine, a clinical and research entity of the University of Pennsylvania. UPHS hospitals include the Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Pennsylvania Hospital, Chester County Hospital, Lancaster General Hospital, Princeton Medical Center, and Doylestown Hospital.
The UPHS is home to the first hospital in the United States, Pennsylvania Hospital.