Urocortin

UCN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RMF, 3N96
Identifiers
Aliases	UCN, UI, UROC, urocortin
External IDs	OMIM: 600945; MGI: 1276123; HomoloGene: 2515; GeneCards: UCN; OMA:UCN - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,308,445 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,296,173 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; primary visual cortex; ; right frontal lobe; ; Brodmann area 9; ; nucleus accumbens; ; gastrocnemius muscle; ; putamen; ; caudate nucleus; ; apex of heart;
	Top expressed in
	muscle of thigh; ; embryo; ; central gray substance of midbrain; ; embryo; ; facial motor nucleus; ; skeletal muscle tissue; ; lip; ; esophagus; ; superior frontal gyrus; ; quadriceps femoris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone deacetylase inhibitor activity; hormone activity; protein binding; neuropeptide hormone activity; G protein-coupled receptor binding; corticotropin-releasing hormone receptor 1 binding; corticotropin-releasing hormone receptor 2 binding; corticotropin-releasing hormone activity;
Cellular component	axon terminus; perikaryon; varicosity; axon; dendrite; soma; extracellular region; extracellular space;
Biological process	positive regulation of collagen biosynthetic process; G protein-coupled receptor signaling pathway; negative regulation of histone deacetylation; activation of protein kinase A activity; response to estradiol; positive regulation of protein phosphorylation; associative learning; startle response; gastric emptying; negative regulation of blood pressure; female pregnancy; negative regulation of gastric acid secretion; negative regulation of apoptotic process; response to glucocorticoid; hearing; pancreatic juice secretion; response to oxidative stress; negative regulation of appetite; positive regulation of translation; negative regulation of gene expression; negative regulation of cell death; positive regulation of peptidyl-serine phosphorylation; positive regulation of DNA replication; aerobic respiration; positive regulation of calcium ion import; positive regulation of cell growth; positive regulation of vascular permeability; positive regulation of gene expression; drinking behavior; response to pain; positive regulation of cardiac muscle contraction; feeding behavior; positive regulation of interleukin-6 production; response to auditory stimulus; learning or memory; social behavior; regulation of synaptic transmission, glutamatergic; inflammatory response; neuropeptide signaling pathway; neuron projection development; negative regulation of necrotic cell death; positive regulation of behavioral fear response; negative regulation of cell size; positive regulation of transcription by RNA polymerase II; negative regulation of neuron death; negative regulation of hormone secretion; negative regulation of feeding behavior; regulation of signaling receptor activity; positive regulation of cAMP-mediated signaling; positive regulation of corticotropin secretion; negative regulation of epinephrine secretion; positive regulation of cortisol secretion; negative regulation of glucagon secretion;
	Sources:Amigo / QuickGO
Orthologs
	7349
	22226
	ENSG00000163794
	ENSMUSG00000038676
	P55089
	P81615
	NM_003353
	NM_021290; NM_001346010
	NP_003344
	NP_001332939; NP_067265
	Wikidata
View/Edit Human	View/Edit Mouse

Urocortin is a protein that in humans is encoded by the UCN gene. Urocortin belongs to the corticotropin-releasing factor (CRF) family of proteins which includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is involved in the mammalian stress response, and regulates aspects of appetite and stress response.