VAT1

VAT1
Identifiers
Aliases	VAT1, VATI, vesicle amine transport 1
External IDs	OMIM: 604631; MGI: 1349450; HomoloGene: 36200; GeneCards: VAT1; OMA:VAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	43,025,123 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,357,056 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; stromal cell of endometrium; ; left adrenal cortex; ; skin of leg; ; tendon of biceps brachii; ; canal of the cervix; ; right lung; ; islet of Langerhans; ; left ovary; ; right ovary;
	Top expressed in
	lip; ; dorsomedial hypothalamic nucleus; ; ciliary body; ; decidua; ; aortic valve; ; otic vesicle; ; suprachiasmatic nucleus; ; supraoptic nucleus; ; gastrula; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; zinc ion binding;
Cellular component	cytoplasm; integral component of membrane; mitochondrial outer membrane; extracellular exosome; membrane; mitochondrion; extracellular region; azurophil granule lumen;
Biological process	negative regulation of mitochondrial fusion; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	10493
	26949
	ENSG00000108828
	ENSMUSG00000034993
	Q99536
	Q62465
	NM_006373
	NM_012037
	NP_006364; NP_006364.2
	NP_036167
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptic vesicle membrane protein VAT-1 homolog is a protein that in humans is encoded by the VAT1 gene.

Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins.

In melanocytic cells VAT1 gene expression may be regulated by MITF.