VAV2

VAV2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ
Identifiers
Aliases	VAV2, VAV-2, vav guanine nucleotide exchange factor 2
External IDs	OMIM: 600428; MGI: 102718; HomoloGene: 2530; GeneCards: VAV2; OMA:VAV2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,992,604 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	27,317,045 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; ganglionic eminence; ; ventricular zone; ; body of pancreas; ; right lobe of liver; ; caput epididymis; ; right adrenal cortex; ; corpus epididymis; ; left adrenal cortex; ; jejunal mucosa;
	Top expressed in
	habenula; ; mesenteric lymph nodes; ; lumbar spinal ganglion; ; medullary collecting duct; ; seminal vesicula; ; cumulus cell; ; seminiferous tubule; ; conjunctival fornix; ; ganglionic eminence; ; molar;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding; metal ion binding; protein binding; phosphotyrosine residue binding;
Cellular component	cytoplasm; cytosol; plasma membrane;
Biological process	regulation of cell size; intracellular signal transduction; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of GTPase activity; ephrin receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; platelet activation; Fc-epsilon receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; cell projection assembly; angiogenesis; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; cell migration; signal transduction; lamellipodium assembly; small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7410
	22325
	ENSG00000160293
	ENSMUSG00000009621
	P52735
	Q60992
	NM_001134398; NM_003371
	NM_009500
	NP_001127870; NP_003362
	NP_033526
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.