VAV3

VAV3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D86
Identifiers
Aliases	VAV3, vav guanine nucleotide exchange factor 3
External IDs	OMIM: 605541; MGI: 1888518; HomoloGene: 38143; GeneCards: VAV3; OMA:VAV3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	107,965,180 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	109,593,014 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; skin of thigh; ; gingival epithelium; ; skin of hip; ; secondary oocyte; ; kidney tubule; ; tibia; ; rectum; ; palpebral conjunctiva; ; hair follicle;
	Top expressed in
	habenula; ; hair follicle; ; medullary collecting duct; ; medial dorsal nucleus; ; granulocyte; ; medial geniculate nucleus; ; spermatid; ; conjunctival fornix; ; Paneth cell; ; lateral geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; epidermal growth factor receptor binding; GTPase activator activity; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; plasma membrane;
Biological process	angiogenesis; Fc-gamma receptor signaling pathway involved in phagocytosis; intracellular signal transduction; ephrin receptor signaling pathway; lamellipodium assembly; regulation of Rho protein signal transduction; positive regulation of phosphatidylinositol 3-kinase activity; vascular endothelial growth factor receptor signaling pathway; small GTPase mediated signal transduction; B cell receptor signaling pathway; cell projection assembly; Fc-epsilon receptor signaling pathway; positive regulation of apoptotic process; integrin-mediated signaling pathway; cellular response to DNA damage stimulus; regulation of cell size; regulation of small GTPase mediated signal transduction; cell migration; platelet activation; vesicle fusion; positive regulation of cell adhesion; positive regulation of B cell proliferation; neutrophil chemotaxis; regulation of GTPase activity; positive regulation of signal transduction; positive regulation of GTPase activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10451
	57257
	ENSG00000134215
	ENSMUSG00000033721
	Q9UKW4
	Q9R0C8
	NM_001079874; NM_006113
	NM_020505; NM_146139; NM_001378987
	NP_001073343; NP_006104
	NP_065251; NP_666251; NP_001365916
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.