VDAC2

VDAC2
Identifiers
Aliases	VDAC2, POR, voltage dependent anion channel 2
External IDs	OMIM: 193245; MGI: 106915; HomoloGene: 37765; GeneCards: VDAC2; OMA:VDAC2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	75,231,448 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	21,895,947 bp
RNA expression pattern
	Top expressed in
	mucosa of esophagus; ; gastrocnemius muscle; ; left ventricle; ; ganglionic eminence; ; right auricle of heart; ; muscle of thigh; ; apex of heart; ; muscle layer of sigmoid colon; ; rectum; ; vagina;
	Top expressed in
	epithelium of stomach; ; spermatid; ; endocardial cushion; ; atrioventricular valve; ; seminiferous tubule; ; mucous cell of stomach; ; pyloric antrum; ; right ventricle; ; migratory enteric neural crest cell; ; vastus lateralis muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	porin activity; nucleotide binding; voltage-gated anion channel activity; protein binding;
Cellular component	integral component of membrane; membrane; synaptic vesicle; myelin sheath; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; membrane raft; mitochondrial nucleoid; extracellular exosome; pore complex; nucleus; acrosomal vesicle;
Biological process	negative regulation of intrinsic apoptotic signaling pathway; ion transport; transmembrane transport; negative regulation of protein polymerization; regulation of anion transmembrane transport; anion transport; anion transmembrane transport; transport; binding of sperm to zona pellucida; inorganic anion transport;
	Sources:Amigo / QuickGO
Orthologs
	7417
	22334
	ENSG00000165637
	ENSMUSG00000021771
	P45880; Q5JSD1
	Q60930
NM_001184783; NM_001184823; NM_003375; NM_001324087; NM_001324088;
	NM_001324089; NM_001324090; NM_001391963
	NM_011695
NP_001171712; NP_001171752; NP_001311016; NP_001311017; NP_001311018;
	NP_001311019; NP_003366
	NP_035825
	Wikidata
View/Edit Human	View/Edit Mouse

Voltage-dependent anion-selective channel protein 2 is a protein that in humans is encoded by the VDAC2 gene on chromosome 10. This protein is a voltage-dependent anion channel and shares high structural homology with the other VDAC isoforms. VDACs are generally involved in the regulation of cell metabolism, mitochondrial apoptosis, and spermatogenesis. Additionally, VDAC2 participates in cardiac contractions and pulmonary circulation, which implicate it in cardiopulmonary diseases. VDAC2 also mediates immune response to infectious bursal disease (IBD).