Vascular endothelial growth factor B

VEGFB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C7W, 2VWE, 2XAC
Identifiers
Aliases	VEGFB, VEGFL, VRF, vascular endothelial growth factor B
External IDs	OMIM: 601398; MGI: 106199; HomoloGene: 87131; GeneCards: VEGFB; OMA:VEGFB - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,239,264 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,965,019 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right auricle of heart; ; right coronary artery; ; left coronary artery; ; popliteal artery; ; tibial arteries; ; Descending thoracic aorta; ; ascending aorta; ; muscle of thigh; ; muscle layer of sigmoid colon;
	Top expressed in
	myocardium; ; myocardium of ventricle; ; right ventricle; ; interventricular septum; ; cardiac muscles; ; muscle of thigh; ; extraocular muscle; ; cardiac muscle tissue of left ventricle; ; digastric muscle; ; plantaris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; protein homodimerization activity; protein binding; protein heterodimerization activity; chemoattractant activity; growth factor activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor 3 binding; vascular endothelial growth factor receptor binding;
Cellular component	membrane; intracellular anatomical structure; extracellular region; platelet alpha granule lumen; extracellular space;
Biological process	negative regulation of neuron apoptotic process; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; cardiac muscle contraction; protein O-linked glycosylation; platelet degranulation; negative regulation of apoptotic process; coronary vasculature development; negative regulation of gene expression; heart development; positive regulation of vascular permeability; positive regulation of vascular wound healing; positive regulation of ERK1 and ERK2 cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell division; positive chemotaxis; response to hypoxia; angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of angiogenesis; vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; positive regulation of mast cell chemotaxis; regulation of signaling receptor activity; positive regulation of protein phosphorylation; sprouting angiogenesis; vascular endothelial growth factor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7423
	22340
	ENSG00000173511
	ENSMUSG00000024962
	P49765
	P49766
	NM_003377; NM_001243733
	NM_001185164; NM_011697
	NP_001230662; NP_003368
	NP_001172093; NP_035827
	Wikidata
View/Edit Human	View/Edit Mouse

Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene. VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member.