Vascular endothelial growth factor C

VEGFC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X1W, 2X1X, 4BSK
Identifiers
Aliases	VEGFC, Flt4-L, LMPH1D, VRP, vascular endothelial growth factor C, LMPHM4
External IDs	OMIM: 601528; MGI: 109124; HomoloGene: 3962; GeneCards: VEGFC; OMA:VEGFC - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	176,792,922 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	54,640,131 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; testicle; ; right lung; ; decidua; ; parietal pleura; ; visceral pleura; ; pericardium; ; subcutaneous adipose tissue;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; semi-lunar valve; ; migratory enteric neural crest cell; ; left lung lobe; ; abdominal wall; ; endocardial cushion; ; aortic valve; ; conjunctival fornix; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chemoattractant activity; protein binding; growth factor activity; vascular endothelial growth factor receptor 3 binding; vascular endothelial growth factor receptor binding;
Cellular component	extracellular region; membrane; platelet alpha granule lumen; extracellular space;
Biological process	negative regulation of cell population proliferation; positive regulation of neuroblast proliferation; positive regulation of protein secretion; substrate-dependent cell migration; signal transduction; positive regulation of protein autophosphorylation; multicellular organism development; morphogenesis of embryonic epithelium; positive regulation of cell-matrix adhesion; positive regulation of mast cell chemotaxis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell division; induction of positive chemotaxis; platelet degranulation; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of blood pressure; positive regulation of cell population proliferation; positive regulation of lymphangiogenesis; regulation of vascular endothelial growth factor receptor signaling pathway; cell differentiation; positive regulation of epithelial cell proliferation; animal organ morphogenesis; positive chemotaxis; angiogenesis; response to hypoxia; positive regulation of endothelial cell proliferation; positive regulation of angiogenesis; cellular response to leukemia inhibitory factor; vascular endothelial growth factor receptor signaling pathway; regulation of signaling receptor activity; positive regulation of protein phosphorylation; sprouting angiogenesis; vascular endothelial growth factor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7424
	22341
	ENSG00000150630
	ENSMUSG00000031520
	P49767
	P97953
	NM_005429
	NM_009506
	NP_005420
	NP_033532
	Wikidata
View/Edit Human	View/Edit Mouse

Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. It is encoded in humans by the VEGFC gene, which is located on chromosome 4q34.