VPREB3

VPREB3
Identifiers
Aliases	VPREB3, 8HS20, N27C7-2, pre-B lymphocyte 3, V-set pre-B cell surrogate light chain 3
External IDs	OMIM: 605017; MGI: 98938; HomoloGene: 7598; GeneCards: VPREB3; OMA:VPREB3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,754,425 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,785,491 bp
RNA expression pattern
	Top expressed in
	lymph node; ; spleen; ; appendix; ; granulocyte; ; mucosa of ileum; ; bone marrow; ; mucosa of transverse colon; ; bone marrow cells; ; blood; ; right adrenal gland;
	Top expressed in
	tibiofemoral joint; ; morula; ; granulocyte; ; tail of embryo; ; spleen; ; embryo; ; genital tubercle; ; embryo; ; blood; ; blastocyst;
	More reference expression data
	More reference expression data
Orthologs
	29802
	22364
	ENSG00000128218
	ENSMUSG00000000903
	Q9UKI3
	n/a
	NM_013378
	NM_009514; NM_001358532
	NP_037510
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.

The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-lymphocyte differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells. In humans, besides the bone marrow and secondary lymphoid tissues such as the tonsils, the VPREB3 protein is also present in Purkinje cells of the cerebellum and in the zona glomerulosa of the adrenal.