VPS35

VPS35
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R17
Identifiers
Aliases	VPS35, MEM3, PARK17, VPS35 retromer complex component, retromer complex component
External IDs	OMIM: 601501; MGI: 1890467; HomoloGene: 6221; GeneCards: VPS35; OMA:VPS35 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	46,689,518 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	86,026,431 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; corpus callosum; ; ganglionic eminence; ; superior frontal gyrus; ; duodenum; ; Achilles tendon; ; islet of Langerhans; ; endometrium; ; monocyte; ; epithelium of colon;
	Top expressed in
	medial ganglionic eminence; ; calvaria; ; parotid gland; ; pyloric antrum; ; dorsomedial hypothalamic nucleus; ; human fetus; ; olfactory epithelium; ; habenula; ; stroma of bone marrow; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; D1 dopamine receptor binding;
Cellular component	cytoplasm; endosome; membrane; tubular endosome; retromer complex; lysosomal membrane; early endosome; extracellular exosome; mitochondrion; lysosome; endosome membrane; postsynaptic density; retromer, cargo-selective complex; mitochondrion-derived vesicle; neuron projection; soma; perinuclear region of cytoplasm; late endosome; cytosol; plasma membrane; presynapse; postsynapse; glutamatergic synapse;
Biological process	regulation of protein stability; positive regulation of canonical Wnt signaling pathway; positive regulation of Wnt protein secretion; transcytosis; negative regulation of late endosome to lysosome transport; retrograde transport, endosome to Golgi; protein transport; regulation of macroautophagy; Wnt signaling pathway; regulation of mitochondrion organization; mitochondrial fragmentation involved in apoptotic process; positive regulation of dopamine receptor signaling pathway; positive regulation of mitochondrial fission; mitochondrion to lysosome transport; neurotransmitter receptor transport, endosome to plasma membrane; regulation of dendritic spine maintenance; regulation of terminal button organization; lysosome organization; positive regulation of gene expression; negative regulation of gene expression; protein destabilization; negative regulation of protein homooligomerization; protein localization to organelle; voluntary musculoskeletal movement; positive regulation of locomotion involved in locomotory behavior; positive regulation of dopamine biosynthetic process; negative regulation of protein localization; negative regulation of lysosomal protein catabolic process; transport; regulation of cellular protein metabolic process; negative regulation of inflammatory response; negative regulation of cell death; negative regulation of neuron death; regulation of presynapse assembly; intracellular protein transport; synapse assembly; viral process; neurotransmitter receptor transport, endosome to postsynaptic membrane; vesicle-mediated transport in synapse; protein localization to endosome;
	Sources:Amigo / QuickGO
Orthologs
	55737
	65114
	ENSG00000069329
	ENSMUSG00000031696
	Q96QK1
	Q9EQH3
	NM_018206
	NM_022997
	NP_060676
	NP_075373
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar protein sorting ortholog 35 (VPS35) is a protein involved in autophagy and is implicated in neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease (AD). VPS35 is part of a complex called the retromer, which is responsible for transporting select cargo proteins between vesicular structures (e.g., endosomes, lysosomes, vacuoles) and the Golgi apparatus. Mutations in the VPS35 gene (VPS35) cause aberrant autophagy, where cargo proteins fail to be transported and dysfunctional or unnecessary proteins fail to be degraded. There are numerous pathways affected by altered VPS35 levels and activity, which have clinical significance in neurodegeneration. There is therapeutic relevance for VPS35, as interventions aimed at correcting VPS35 function are in speculation.