VPS52

VPS52
Identifiers
Aliases	VPS52, ARE1, SAC2, SACM2L, dJ1033B10.5, GARP complex subunit, VPS52 subunit of GARP complex
External IDs	OMIM: 603443; MGI: 1330304; HomoloGene: 5756; GeneCards: VPS52; OMA:VPS52 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,272,047 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,186,009 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right uterine tube; ; pituitary gland; ; right adrenal cortex; ; left lobe of thyroid gland; ; right hemisphere of cerebellum; ; spleen; ; anterior pituitary; ; left adrenal cortex; ; right ovary;
	Top expressed in
	granulocyte; ; superior frontal gyrus; ; primary visual cortex; ; muscle of thigh; ; lip; ; spermatocyte; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; right kidney; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syntaxin binding; protein binding;
Cellular component	perinuclear region of cytoplasm; recycling endosome; EARP complex; endosome; Golgi apparatus; endosome membrane; membrane; trans-Golgi network membrane; GARP complex; cytosol;
Biological process	protein transport; ectodermal cell differentiation; embryonic ectodermal digestive tract development; endocytic recycling; lysosomal transport; Golgi to vacuole transport; retrograde transport, endosome to Golgi;
	Sources:Amigo / QuickGO
Orthologs
	6293
	224705
ENSG00000236014; ENSG00000206286; ENSG00000223501; ENSG00000224455; ENSG00000225590;
	ENSG00000223618; ENSG00000228425
	ENSMUSG00000024319
	Q8N1B4
	Q8C754
	NM_001289174; NM_001289175; NM_001289176; NM_022553
	NM_172620; NM_001357329; NM_001357330; NM_001379410; NM_001379411
	NP_001276103; NP_001276104; NP_001276105; NP_072047
	NP_766208; NP_001344258; NP_001344259; NP_001366339; NP_001366340
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.

This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18.