VWA2

VWA2
Identifiers
Aliases	VWA2, AMACO, CCSP-2, NET42, von Willebrand factor A domain containing 2, CCSP2
External IDs	OMIM: 618281; MGI: 2684334; HomoloGene: 18238; GeneCards: VWA2; OMA:VWA2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	114,294,489 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	56,900,510 bp
RNA expression pattern
	Top expressed in
	thymus; ; right uterine tube; ; olfactory zone of nasal mucosa; ; sural nerve; ; testicle; ; body of stomach; ; fundus; ; skin of abdomen; ; body of pancreas; ; skin of leg;
	Top expressed in
	otic vesicle; ; molar; ; secondary oocyte; ; primary oocyte; ; lip; ; tail of embryo; ; proximal tubule; ; genital tubercle; ; cervix; ; pulmonary alveolar epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; identical protein binding; calcium ion binding;
Cellular component	extracellular region; basement membrane; extracellular exosome; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	calcium-independent cell-matrix adhesion; protein homooligomerization; regulation of insulin receptor signaling pathway; growth plate cartilage chondrocyte morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	340706
	240675
	ENSG00000165816
	ENSMUSG00000025082
	Q5GFL6
	Q70UZ7
	NM_001272046; NM_198496; NM_001320804
	NM_172840
	NP_001258975; NP_001307733
	NP_766428
	Wikidata
View/Edit Human	View/Edit Mouse

von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO), is a protein that in humans is encoded by the VWA2 gene.

AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain. AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.

AMACO binds directly to FRAS1 which is part of the Fraser complex important for epithelial-connective tissue interaction, the exact biological role of AMACO, however, is still unknown. In 2005 AMACO was found markedly induced in colon cancers; indicating that it might be a good candidate as a biomarker for this type of cancer.