Valsartan

Valsartan
Clinical data
Trade names	Diovan, others
AHFS/Drugs.com	Monograph
MedlinePlus	a697015
License data	US DailyMed: Valsartan;
Pregnancy; category	AU: D;
Routes of; administration	By mouth
Drug class	Angiotensin II receptor antagonist
ATC code	C09CA03 (WHO) C09DX05 (WHO), C09DA03 (WHO), C09DX02 (WHO), C09DX01 (WHO), C09DB08 (WHO), C09DB01 (WHO), C09DX04 (WHO), C10BX10 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	25%
Protein binding	95%
Elimination half-life	6 hours
Excretion	Kidney 30%, bile duct 70%
Identifiers
	IUPAC name (S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}pentanamido)butanoic acid;
CAS Number	137862-53-4 ;
PubChem CID	60846;
IUPHAR/BPS	3937; tritiated: 593;
DrugBank	DB00177 ;
ChemSpider	54833 ;
UNII	80M03YXJ7I;
KEGG	D00400 ;
ChEBI	CHEBI:9927 ;
ChEMBL	ChEMBL1069 ;
CompTox Dashboard (EPA)	DTXSID6023735 ;
ECHA InfoCard	100.113.097
Chemical and physical data
Formula	C24H29N5O3
Molar mass	435.528 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(C(=O)O)C(C)C;
	InChI InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1 ; Key:ACWBQPMHZXGDFX-QFIPXVFZSA-N ;
	(verify)

Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs). It is a reasonable initial treatment for high blood pressure. It is taken by mouth.

Common side effects include feeling tired, dizziness, high blood potassium, diarrhea, and joint pain. Other serious side effects may include kidney problems, low blood pressure, and angioedema. Use in pregnancy may harm the baby and use when breastfeeding is not recommended. It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II.

Valsartan was patented in 1990, and came into medical use in 1996. It is available as a generic medication. In 2022, it was the 117th most commonly prescribed medication in the United States, with more than 5 million prescriptions.