Vault (organelle)

Vault, N-terminal repeat domain
Structure of the Vault complex from rat liver.
Identifiers
SymbolVault
PfamPF01505
InterProIPR002499
PROSITEPDOC51224
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB2ZUO 2ZV4 2ZV5

The vault or vault cytoplasmic ribonucleoprotein is a eukaryotic organelle (a structure in the cells of multicellular organisms) whose function is not yet fully understood. Discovered and isolated by Nancy Kedersha and Leonard Rome in 1986, vaults are cytoplasmic structures (outside the nucleus) which, when negative-stained and viewed under an electron microscope, resemble the arches of a cathedral's vaulted ceiling, with 39-fold (or D39d) symmetry. They are present in many types of eukaryotic cells and appear to be highly conserved among eukaryotes.

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