Vimentin

VIM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GK4, 1GK6, 1GK7, 3G1E, 3KLT, 3S4R, 3SSU, 3SWK, 3TRT, 3UF1, 4MCY, 4MCZ, 4MD0, 4MD5, 4MDJ, 4YPC, 4YV3
Identifiers
Aliases	VIM, CTRCT30, HEL113, vimentin
External IDs	OMIM: 193060; MGI: 98932; HomoloGene: 2538; GeneCards: VIM; OMA:VIM - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	17,237,593 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	13,587,637 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; Descending thoracic aorta; ; right coronary artery; ; synovial membrane; ; spinal ganglia; ; popliteal artery; ; tibial arteries; ; decidua; ; ascending aorta; ; tibial nerve;
	Top expressed in
	endothelial cell of lymphatic vessel; ; left lung lobe; ; dermis; ; Gonadal ridge; ; external carotid artery; ; tunica media of zone of aorta; ; stroma of bone marrow; ; internal carotid artery; ; ascending aorta; ; semi-lunar valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	scaffold protein binding; structural molecule activity; structural constituent of cytoskeleton; protein C-terminus binding; protein binding; structural constituent of eye lens; identical protein binding; double-stranded RNA binding; keratin filament binding; protein domain specific binding;
Cellular component	cytoplasm; cytosol; cell projection; focal adhesion; plasma membrane; peroxisome; cell leading edge; neuron projection; extracellular exosome; cytoskeleton; intermediate filament; extracellular matrix; nucleus; polysome; nuclear matrix; phagocytic vesicle; ribonucleoprotein complex;
Biological process	intermediate filament organization; negative regulation of neuron projection development; SMAD protein signal transduction; astrocyte development; intermediate filament-based process; positive regulation of gene expression; muscle filament sliding; Bergmann glial cell differentiation; viral process; lens fiber cell development; cytokine-mediated signaling pathway; positive regulation of collagen biosynthetic process; regulation of mRNA stability; positive regulation of translation; cellular response to lipopolysaccharide; cellular response to muramyl dipeptide; cellular response to interferon-gamma;
	Sources:Amigo / QuickGO
Orthologs
	7431
	22352
	ENSG00000026025
	ENSMUSG00000026728
	P08670
	P20152
	NM_003380
	NM_011701
	NP_003371
	NP_035831
	Wikidata
View/Edit Human	View/Edit Mouse

Vimentin is a structural protein that in humans is encoded by the VIM gene. Its name comes from the Latin vimentum which refers to an array of flexible rods.

Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all animal cells as well as bacteria. Intermediate filaments, along with tubulin-based microtubules and actin-based microfilaments, comprise the cytoskeleton. All IF proteins are expressed in a highly developmentally-regulated fashion; vimentin is the major cytoskeletal component of mesenchymal cells. Because of this, vimentin is often used as a marker of mesenchymally-derived cells or cells undergoing an epithelial-to-mesenchymal transition (EMT) during both normal development and metastatic progression.