Vitronectin

VTN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OC0, 1S4G, 1SSU, 2JQ8, 3BT1, 3BT2, 4K24
Identifiers
Aliases	VTN, V75, VN, VNT, vitronectin
External IDs	OMIM: 193190; MGI: 98940; HomoloGene: 532; GeneCards: VTN; OMA:VTN - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,373,091 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,393,150 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; gallbladder; ; left ventricle; ; apex of heart; ; placenta; ; right hemisphere of cerebellum;
	Top expressed in
	neural layer of retina; ; left lobe of liver; ; gallbladder; ; optic nerve; ; retinal pigment epithelium; ; dentate gyrus of hippocampal formation granule cell; ; epithelium of lens; ; sexually immature organism; ; fetal liver hematopoietic progenitor cell; ; pia mater;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; scavenger receptor activity; heparin binding; extracellular matrix binding; polysaccharide binding; integrin binding; identical protein binding; collagen binding; extracellular matrix structural constituent;
Cellular component	alphav-beta3 integrin-vitronectin complex; extracellular exosome; blood microparticle; Golgi lumen; basement membrane; rough endoplasmic reticulum lumen; cytoplasm; extracellular matrix; extracellular space; endoplasmic reticulum; intracellular membrane-bounded organelle; extracellular region; collagen-containing extracellular matrix;
Biological process	receptor-mediated endocytosis; positive regulation of protein binding; cell adhesion; positive regulation of cell-substrate adhesion; extracellular matrix organization; smooth muscle cell-matrix adhesion; regulation of complement activation; positive regulation of smooth muscle cell migration; negative regulation of endopeptidase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; immune response; endodermal cell differentiation; positive regulation of wound healing; positive regulation of receptor-mediated endocytosis; negative regulation of blood coagulation; oligodendrocyte differentiation; cell adhesion mediated by integrin; cell-matrix adhesion; protein polymerization; liver regeneration; cell population proliferation; cell migration; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	7448
	22370
	ENSG00000109072
	ENSMUSG00000017344
	P04004
	P29788
	NM_000638
	NM_011707
	NP_000629
	NP_035837
	Wikidata
View/Edit Human	View/Edit Mouse

Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is synthesized and excreted by the liver, and abundantly found in serum, the extracellular matrix and bone. In humans it is encoded by the VTN gene.

Vitronectin binds to integrin alpha-V beta-3 and thus promotes cell adhesion and spreading. It also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpins (serine protease inhibitors). It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. Vitronectin has been speculated to be involved in hemostasis and tumor malignancy.