Voriconazole
| Clinical data | |
|---|---|
| Pronunciation | /vɒrɪˈkɒnəzoʊl/ vorr-i-KON-ə-zohl |
| Trade names | Vfend, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a605022 |
| License data |
|
| Pregnancy category |
|
| Routes of administration | Intravenous, by mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 96% (oral) |
| Protein binding | 58% |
| Metabolism | Liver: CYP2C19 (significant involvement), also CYP2C9, CYP3A4 |
| Metabolites | Voriconazole N-oxide (major; minimal antifungal activity) |
| Elimination half-life | Dose-dependent |
| Excretion | Urine (80–83%) |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.157.870 |
| Chemical and physical data | |
| Formula | C16H14F3N5O |
| Molar mass | 349.317 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
Voriconazole, sold under the brand name Vfend among others, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, candidiasis, coccidioidomycosis, histoplasmosis, penicilliosis, and infections by Scedosporium or Fusarium. It can be taken by mouth or used by injection into a vein.
Common side effects include vision problems, nausea, abdominal pain, rash, headache, and seeing or hearing things that are not present. Use during pregnancy may result in harm to the baby. It is in the triazole family of medications. It works by affecting fungal metabolism and fungal cell membranes.
Voriconazole was patented in 1990 and approved for medical use in the United States in 2002. It is on the World Health Organization's List of Essential Medicines.